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MRC HOLLAND
MRC Holland is a company based out of The Netherlands which has a proprietary technology – MLPA® (Multiplex Ligation-dependant Probe Amplification (MLPA®), a multiplex PCR method which enables detection of variation in copy number (CNV) of up to 60 DNA sequences in one reaction and can handle up to 96 DNA samples at a stretch with results being available within 24 hours.
Introduced in 2002, MLPA® is a gold standard in CNV detection and has proven to be a robust and easy-to-use techniques, and since it is highly sensitive to even a single nucleotide difference, it has applications in detection of point mutations.
MLPA®, when used in combination with a methylation-sensitive restriction enzyme, can be applied to detect DNA methylation patterns (MS_MLPA®). The first Melt Assay for spinal muscular atrophy (SMA) newborn screening was launched in 2018 and the first digitalMLPA® technique based assay was launched in 2020. digitalMLPA® combines the trusted quality of MLPA® with the power of next-generation sequencing to examine many more target sequences in a single reaction.
In diagnostics and research of both human genetic disorders and tumors, MLPA® is used in laboratories worldwide.
D001 Hereditary Cancer Panel
SALSA® digital Multiplex Ligation-dependent Probe Amplification (digitalMLPA) is a multiplex PCR followed by Illumina sequencing-based amplicon quantification, for the detection of copy number variations (CNV) and specific point mutations.
Applications & Specialities, Cancer Diagnostics, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND
Methylation-Specific MLPA Assays
Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. With MS-MLPA, it is possible to semi-quantitatively profile methylation for multiple targets simultaneously.
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Lung Disorders
MLPA Assays are useful in finding out those who have Lung Disorders
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Cardiovascular Disorders
MLPA can be used for the detection of deletions or duplications of certain genes involved in cardiovascular diseases.
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Endocrinological Disorders
MLPA Assays are useful in finding out those who have endocrinological diseases.
Applications & Specialities, MLPA, MLPA, MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Hereditary Blood Disorders
MLPA Assays are useful in finding out those who have hereditary blood disorders.
Applications & Specialities, Congenital & Hereditary Disorders, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Intellectual Disability
MLPA Assays are useful in finding out those who have Intellectual Disability
Applications & Specialities, Genetic Disorders, Intellectual Disability, Intellectual property, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Neuromuscular Disorders
MLPA Assays are useful in finding out those who have Neuromuscular Disorders
Applications & Specialities, MLPA, MLPA, MRC HOLLAND, Clinical Diagnostics
MLPA Assays for Skeletal & Connective Tissue
MLPA Assays are useful in finding out those who have Skeletal & Connective Tissue Disorders
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND
MLPA Assays for Tumour Profiling
MLPA Assays are useful in tumor profiling for blood cancer, solid tumors as well as general tumor profiling
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), Solid Tumor, Tumours Profiling, MRC HOLLAND, Clinical Diagnostics
MLPA Probemixes for Cancer Predisposition
SALSA® MLPA® Probemixes for Cancer Predisposition are used for determining DNA copy number variations in individuals who have a genetic predisposition to various cancers, including breast, ovarian, colorectal, endometrial, gastric, and small bowel cancer, among others. MLPA Assay is a simple, robust and multiplex PCR-based assay.
Applications & Specialities, Early cancer detection, Genetic Disorders, MLPA, MLPA, Products & Services, MRC HOLLAND, Clinical Diagnostics
MLPA Probemixes for Congenital Disorders & Carrier Testing
SALSA® MLPA® Probemixes for Congenital Disorders & Carrier Testing are used for determining DNA copy number variations in inherited disorders such as Alpha-Thalassemia (P140 HBA) , Congenital Adrenal Hypoplasia (P050 CAH), Cystic Fibrosis (P091 CFTR), Duchenne Muscular Dystrophy (P034 DMD-1; P035 DMD-2) and Spinal Muscular Atrophy (P021 SMA; P060 SMA Carrier; P460 SMA (Silent) Carrier).
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Products & Services, MRC HOLLAND
MLPA Probemixes for Imprinting Disorders
SALSA® Methylation - Specific (MS) - MLPA® Probemixes for Imprinting Disorders are used for determining DNA copy number variations and methylation status associated with conditions like Prader-Willi Syndrome, Angelman Syndrome, Beckwith-Wiedemann and Russell-Silver Syndrome.
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Products & Services, MRC HOLLAND, Clinical Diagnostics
SALSA® digitalMLPA Probemix D006 Multiple Myeloma
The SALSA digitalMLPAProbemix D006-A1 Multiple Myeloma is a research use only (RUO) assay for the detection of deletions, gains or amplifications of genes and chromosomal regions mentioned in Table 2 that are recurrently altered in multiple myeloma, such as 1p, 1q, 13q and 17p, as well as for the detection of BRAF p.V600E point mutation.
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
SALSA® digitalMLPA Probemix D007 Acute Lymphoblastic Leukemia
The SALSA digitalMLPA Probemix D007-A1 Acute lymphocytic leukemia is a research-use-only (RUO) assay for the detection of deletions, gains or amplifications in 52 specific target genes and three chromosomal regions (5q, iAMP21 and PAR1), which are related to acute lymphoblastic leukemia (ALL).
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND, Clinical Diagnostics
SALSA® Melt Assays
SALSA® Melt Assays are designed for the fast and reliable screening of a small number of targets in a large number of samples.
Applications & Specialities, Genetic Disorders, MLPA, MLPA, Multiplex Ligation-Dependent Probe Amplification (MLPA), MRC HOLLAND
Testimonials & Reviews
Dr. Chhaya Chande, Professor & HOD, Microbiology
GGMCJJ Hospitals, Mumbai
“Ms. Megha Dhumal (Assistant Manager- Application) has done a satisfactory demonstration of the running of the Abbott Sample preparation machine model m2000sp and the Abbott RT-PCR machine model m2000rt. We appreciate the effort made by the DSS team under these difficult conditions to help our lab to carry out the imperative Covid-19 tests.”
Dr Sunil K Arora, Professor, Deptt of Immunopathology
PGIMER, Chandigarh
“We are using Confocal Microscope and one Fluorescence Microscope. Both are working fine. The after sales services by DSS have been excellent for functioning & upkeep of the microscopes. The applications support by experts from DSS is very useful. Keep it up!”
Dr Pramod Kumar Bajaj
MD, Spermprocessor Pvt Ltd
“Really excited to see the DSS Pathology solutions exhibition booth at APCON 2019 along with Magnus. We think all the upcoming technology had been displayed along with your efforts to make it Indigenous (Made in India) is highly appreciated. Wish you all the best. Keep it up!”
Dr. Sreejesh S, Associate Professor, Dept of Hematology
PGIMER, Chandigarh
“My experience with DSS so far has been very good till now. We are getting good support in both purchase as well as in troubleshooting. Very good experience with Mr Arun, Mr Manoj, Mr Mahesh and all others from the DSS team.”
Dr Sudha S Murthy, Department of Pathology and Laboratory Medicine
BIACH & RI, Hyderabad
“I am happy with DSS and associated with 19 years and use Dako antibody. Happy with Supply but need improvement.”
Dr S Radhika MD, PhD
Professor, Deptt. Of Cytology & Gynaec Pathology, PGIMER, Chandigarh
“PGI Cytology Dept. has had a long association with DSS- Olympus Microscopy Division. They have provided excellent services- after sales service. The product is also of very good quality. We have had no problems with their products and services are of very good quality.”
Dr Nuzhat Husain
RMLIMS, Lucknow
“Have been using Dako Reagants and Dako antibodies for a while. Services and products have been good and timely.”
Dr Minu Singh
Assistant Professor, PGIMER, Chandigarh
“MRC Holland MLPA products provided by DSS are of good quality, have never faced any quality issues with their product or shipping condition. They provide prompt response upon any query.”
Mr. Krishnani Professor, SGPGI, Lucknow
“My experience with DSS so far has been excellent for the last 30 years- sales and service experience. Microscope products are very useful and sturdy with high precision.”
